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    NMDA Receptor Hypofunction Leads to Generalized and Persistent gamma Frequency (30-80 Hz) Oscillations: Signal and Noise in Corticothalamic Systems
    Date:
    10/24/2014
    Speaker:
    Prof. Didier Pinault
    INSERM, Université de Strasbourg, Faculté de médecine Strasbourg, France
    Title:
    NMDA Receptor Hypofunction Leads to Generalized and Persistent gamma Frequency (30-80 Hz) Oscillations: Signal and Noise in Corticothalamic Systems
    Abstract:
    N-methyl D-aspartate type glutamate receptor antagonists induce schizophreniform disorder symptoms accompanied with deficits in sensory-perception and cognition and with a persistent amplification of electroencephalographic baseline gamma frequency (30-80 Hz) oscillations in cortical and subcortical regions, including the thalamus. This generalized network gamma noise might be the source of abnormal activities (e.g, during hallucinations) and disturb function-related synchronized oscillations. The corresponding gamma signal-to-noise ratio is proposed as a potential electrophysiological biomarker of network dysfunctions responsible for disturbances in sensorimotor and cognitive information processing associated with mental disorders. Testing theoretical and pathophysiological hypotheses is an appealing and promising basic-clinical translational way to understand how, in health and disease, our brain at work combines its various and miscellaneous molecular, synaptic, cellular and architectural complexities.
    Place:
    University of Heidelberg, INF 306, SR 14
    15:00-16:00