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    Pathway-specific gating and modulation of synaptic plasticity in the hippocampus
    Date:
    07/11/2014
    Speaker:
    Dr. Georg Köhr, Physiology of Neural Networks, Joint Research Group , Psychiatry/Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Title:
    Pathway-specific gating and modulation of synaptic plasticity in the hippocampus
    Abstract:
    Input-specific synaptic plasticity in central synapses requires the coincident activation of pre- and postsynaptic neurons, consistent with Hebb’s postulate, whereas some forms of non-Hebbian synaptic plasticity can be induced by postsynaptic activity alone. We found that non-Hebbian synaptic plasticity in hippocampal CA1 pyramidal cells can be arrested by synaptic activity in apical but not basal dendrites, which receive learned and new sensory information. This pathway-specific gating of synaptic plasticity may regulate information flow through the hippocampal network. In addition, subcortical neuromodulatory circuits involved in sleep-wake control also regulate conscious cognitive processes. We examined the consequences of dopamine release in hippocampal slices and in awake mice and found modulation of synaptic plasticity at basal but not apical CA1 synapses via D4 dopamine receptor activation.
    Place:
    CIMH Mannheim, Therapy Building, big lecture hall, 15:00-16:00