Abstract:
Pyramidal cells of the hippocampal CA1 region were formerly treated as quite uniform neuronal population. However, recent publications distinguish several subgroups of cells differing in molecular markers, spatial distribution, firing properties and dendritic arborisation. In the course of our experiments, we found CA1 pyramidal neurons which had shifted its axonal basis to a proximal basal dendritic branch. This morphology has previously been observed in principal parietal cortex neurons (rat), pyramidal cells of the motor cortex (primate) and hippocampal CA1 area (rat). But neither their distribution in the hippocampal structure nor electrophysiological properties were further investigated or described so far. We tackle this questing combining methods from genetics, immunhistochemistry, patch clamp, two photon uncaging and computer simulations.