Maria V. Sanchez-Vives, ICREA Research Professor, IDIBAPS,
The default activity of the cortical network is the generation of different rhythmic patterns, and a prominent one is the generation of slow oscillations or Up and Down states. This activity is not only prominent during slow wave sleep and profound anesthesia, but also in spontaneously active cortical slices. Emergent cortical activity is sculpted by cellular properties and synaptic connectivity in the network. In this presentation I will present data obtain from in vitro and in vivo cortex and discuss some of the mechanisms that contribute to the shaping of oscillatory patterns, including inhibition, potassium currents and synaptic depression.