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Sartorius group

Principal investigator:
Klinik für Psychiatrie und Psychotherapie
Medizinische Fakultät Mannheim, Universität Heidelberg
Zentralinstitut für Seelische Gesundheit (ZI)
J5, D-68159 Mannheim


General research interests and goals:

The Research Group Translational Imaging belongs to the Department of Neuroimaging and to the Department of Psychiatry and Psychotherapy. Its goal is to establish and optimize translational imaging at a high field 9.4T animal scanner.

Bridging the gap between preclinical and clinical research is essential for the development in psychiatric research. We want to realize this step via Translational Imaging. In the preclinical part there currently exist excellent and well validated genetic and behavioral animal models for alcohol dependency, depression, dementia and other psychiatric illnesses. E.g. we use genetic animal models of psychiatric diseases by means of breeding or specific elimination of individual genes for intermediate endophenotyping. With the use of high-field MRI we take advantage of a tool that enables multiple intra-individual measurements and therefore the direct quantification of gene x environment x therapy interactions on brain function.

Specific research foci are establishment and optimization of optogenetic fMRI (og-fMRI), functional measurements of brain function like resting-state fMRI, cASL, rCBV, multi nuclear magnetic resonance spectroscopy (MRS) of 1H, 13C and 31P , voxel based morphometry (VBM), and fiber-tracking with DTI. Furthermore, multiple surface-, volume-, multi array and two cryo-coils (1H and 13C) are available.



Current group members:

PhD students: Claudia Falfán-Melgoza / Philipp Lebhardt
Associates: Wolfgang Weber-Fahr / Dirk Cleppien / Natalia Gass / Markus Sack / Christian Clemm von Hohenberg

Key publications:

Lebhardt P, Hohenberg CC, Weber-Fahr W, Kelsch W, Sartorius A (2016) Optogenetic fMRI in the mouse hippocampus: hemodynamic response to brief glutamatergic stimuli J Cereb Blood Flow Metab. 2016 Mar;36(3):629-38 .
Schwarz AJ, Gass N, Sartorius A, Zheng L, Spedding M, Schenker E, Risterucci C, Meyer-Lindenberg A, Weber-Fahr W (2013) The low-frequency blood oxygenation level-dependent functional connectivity signature of the hippocampal-prefrontal network in the rat brain Neuroscience. 2013 Jan 3;228:243-58 .
Schwarz AJ, Gass N, Sartorius A, Risterucci C, Spedding M, Schenker E, Meyer-Lindenberg A, Weber-Fahr W (2013) Anti-correlated cortical networks of intrinsic connectivity in the rat brain Brain Connect. 2013;3(5):503-11 .