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Meyer-Lindenberg group

Principal investigator:
Zentralinstitut für Seelische Gesundheit
J 5
68159 Mannheim


General research interests and goals:

Our group is interested in neural risk mechanisms for severe psychiatric disorders, especially schizophrenia, depression, and bipolar disorder, and neural systems related to social (dys-)function. We use a combination of techniques, with a focus on combining neuroimaging and genetic information. We have worked extensively on the characterization of executive processes in prefrontal cortex and prefrontally-linked circuits in healthy humans and psychiatric patients using a combination of multimodal neuroimaging and genetics. In particular, we have investigated the impact of dopaminergic neurotransmission, global changes in connectivity and studied a broad range of candidate and genome-wide significant variants. We are a mainly experimental group with theoretical interests in characterizing brain connectivity and complex brain-gene networks.



Current group members:

Associates: Luanna Dixson

Key publications:

Bahner F, Meyer-Lindenberg A (2017) Hippocampal-prefrontal connectivity as a translational phenotype for schizophrenia. Eur Neuropsychopharmacol, 27(2), 93-106. doi:10.1016/j.euroneuro.2016.12.007 .
Bahner F, Demanuele C, Schweiger J, Gerchen MF, Zamoscik V, Ueltzhoffer K, Meyer-Lindenberg A (2015) Hippocampal-dorsolateral prefrontal coupling as a species-conserved cognitive mechanism: a human translational imaging study. Neuropsychopharmacology, 40(7), 1674-1681. doi:10.1038/npp.2015.13 .
Demanuele C, Bahner F, Plichta MM, Kirsch P, Tost H, Meyer-Lindenberg A, Durstewitz D (2015) A statistical approach for segregating cognitive task stages from multivariate fMRI BOLD time series. Front Hum Neurosci, 9, 537. doi:10.3389/fnhum.2015.00537 .
Demanuele C, Kirsch P, Esslinger C, Zink M, Meyer-Lindenberg A, Durstewitz D (2015) Area-specific information processing in prefrontal cortex during a probabilistic inference task: a multivariate fMRI BOLD time series analysis. PLoS One, 10(8), e0135424. doi:10.1371/journal.pone.0135424 .
Meyer-Lindenberg AS, Olsen RK, Kohn PD, Brown T, Egan MF, Weinberger DR, Berman KF (2005) Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. Arch Gen Psychiatry. 2005 Apr;62(4):379-86 .